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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 12, Issue 2 (2023)

Formulation and evaluation of bi-layered tablet of divalproex sodium

Author(s):

Ajaz Ahmad, Satkar Prasad and Gaurav Dubey

Abstract:

Objective: To Formulate and Evaluate bi-layered tablet of Divalproex Sodium.

Method: Divalproex sodium is broad-spectrum anticonvulsant. It increases the availability of gamma- amino butyric acid (GABA), an inhibitory neurotransmitter, The bilayer tablet of Divalproex sodium were prepared by using sodium starch glycolate, croscarmellose sodium, lactose, microcrystalline cellulose, polyvinyl pyrrolidone, magnesium stearate, talc, hydroxyl propyl methyl cellulose, as Excipents using wet granulation by using different Superdisintegrants.

Result: In the present work, formulation and evaluation of bi-layered tablet of Divalproex sodium was carried out. In the project, different formulations of immediate release and sustained release layer have been prepared separately. From above formulations best formulation of each immediate and sustained release layers were selected according to the dissolution profile and bi- layered tablet were prepared.

Conclusion: In the present work bi-layered tablet of Divalproex sodium were prepared by wet granulation method, using super disintegrants such as sodium starch glycolate and croscarmellose for immediate release layer and polymer like HPMC K4M and HPMC K100M for sustained release layer. Best formulations of each layer were selected for bi-layered tablet and bi-layered tablet were prepared. Bi-layered tablet of Divalproex sodium were subjected to hardness, weight variation, friability, drug content uniformity, in vitro drug release and drug polymer interaction.

Pages: 16-22  |  986 Views  523 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Ajaz Ahmad, Satkar Prasad and Gaurav Dubey. Formulation and evaluation of bi-layered tablet of divalproex sodium. J Pharmacogn Phytochem 2023;12(2):16-22. DOI: 10.22271/phyto.2023.v12.i2a.14621

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