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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 12, Issue 3 (2023)

Evaluation of the antispasmodic potential of leaf extracts of Albizia zygia on isolated rabbit jejunum

Author(s):

Nkiruka Philomena Okoye, Oto-Obong V IDah, Timothy Olugbenga Ogundeko, Modupe Builders and Kemakolam Amadi

Abstract:

Medicinal plants have been proven to be effective in the management of numerous ailments across the globe over the years. Many African plants have also been identified with gastrointestinal-relaxation properties. Albizia zygia is used traditionally to treat various illnesses, including those related to the digestive system. This study aimed to compare the antispasmodic effect of aqueous and crude leaf extracts of Albizia zygia (ALEAZ and CLEAZ) on an isolated rabbit jejunum. Aqueous and crude extracts of the plant material was prepared via Soxhlet extraction and maceration respectively. The antispasmodic effect was evaluated in vitro (37 ºC, pH 7.4 with continuous oxygenation). Both ALEAZ and CLEAZ caused spontaneous relaxation of the rabbit’s jejunum with a maximal effect at 0.2ml (0.15g/ml). This study further showed that the mechanism of action of the relaxation was not dependent on the muscarinic, histaminergic receptors nor through voltage-gated calcium channel (VGCs) blockade. These suggests that aqueous and crude leaf extracts of Albizia zygia have spasmolytic effect on isolated rabbit jejunum, thus authenticates its folkloric use in the treatment of gastrointestinal disorders.

Pages: 24-28  |  361 Views  153 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Nkiruka Philomena Okoye, Oto-Obong V IDah, Timothy Olugbenga Ogundeko, Modupe Builders and Kemakolam Amadi. Evaluation of the antispasmodic potential of leaf extracts of Albizia zygia on isolated rabbit jejunum. J Pharmacogn Phytochem 2023;12(3):24-28.

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