Monika Singh, Shikhar Verma and Abhishek Shah
Seven to ten million people worldwide suffering with Parkinson’s disease (PD).it is most prevalent neurodegenerative condition. Substantia Nigra (SNc) is hallmark of PD, increasing loss of dopaminergic neurons in the substantia Nigra pars compacta (SNc). The symptoms motor functions, such as resting tremor, stiffness, bradykinesia, and postural instability, are caused by the nigrostriatal pathway. According to research data a number of molecular mechanisms, including as oxidative stress, neuro inflammation, and α-synuclein (α-syn) aggregation and crucial in the pathogenesis of PD. Over the year, neuroinflammation and oxidative stress have been found in the etiology of this disease. Due to this research, recently focused on identifying and analysing novel natural molecules in order to create potential effect on PD. Natural polyphenols have lots of interest in this content because of their therapeutic effects. In this review we plan to summarise pertinent in vivo research, mechanism and chemical constituents on the possible therapeutic value of natural polyphenols and alkaloids in PD.
Pages: 129-139 | 456 Views 163 Downloads