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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 12, Issue 5 (2023)

Exploring the anti-inflammatory and antimicrobial potential of Smilax zeylanica extract through in vivo and in vitro analysis

Author(s):

Lakshyajeet Nath, Rosy Ahmed, Bhaswati Kashyap, Himshikhar Sarma, Nilutpal Sharma Bora, Sameeran Gam, Kangkan Deka, Sanduwinaki Siangshai, Bhargab Jyoti Sahariah and Dr. Koushik Nandan Dutta

Abstract:

Plants have long been used as supplies of food, building materials, textiles, spices, colours, and medicines. Most rural communities have traditionally relied heavily on the traditional healing system to maintain both physical and mental health. The bioactive components from the leaf extract of Smilax zeylanica L demonstrated strong anti-inflammatory and antibacterial action in the current study. The leaf extract had a maximum inhibition of protein denaturation with 78.65% at 150 µg/ml concentration, compared to the standard drug aspirin which had an inhibition of 67.69% at 150 µg/ml. The in vivo anti-inflammatory analysis also showed reduction in edema percentage with increasing in the concentration of test extract over time. The in vitro antimicrobial activity of leaf extract against S aureus, E coli was evaluated at various concentrations (1, 2 and 4 mg). The maximum zone of inhibition was observed against S. aureus as compared to E. coli. Total phenolic (TPC) and total flavonoid contents (TFC) of the crude extract were also determined by Folin–Ciocalteu’s phenol reagent and by aluminium chloride method respectively.

Pages: 273-279  |  481 Views  182 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Lakshyajeet Nath, Rosy Ahmed, Bhaswati Kashyap, Himshikhar Sarma, Nilutpal Sharma Bora, Sameeran Gam, Kangkan Deka, Sanduwinaki Siangshai, Bhargab Jyoti Sahariah and Dr. Koushik Nandan Dutta. Exploring the anti-inflammatory and antimicrobial potential of Smilax zeylanica extract through in vivo and in vitro analysis. J Pharmacogn Phytochem 2023;12(5):273-279. DOI: 10.22271/phyto.2023.v12.i5c.14737

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