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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 13, Issue 1 (2024)

Mechanistic insight anti-arthritis efficacy of bio-actives of Moringa oleifera: In-silico molecular docking

Author(s):

Jitender Malik, Deepak Jhariya, Priyanka Ahirwar, Shikha Sharma, Sadhana Upadhyay and Himesh Soni

Abstract:

Background: Rheumatoid arthritis (RA), an autoimmune, inflammatory, and chronic condition, affects patients differently in terms of how severely it affects their joints. Risk factors include age, gender, genetics, and environmental exposure (tobacco usage, air pollution exposure, and occupational exposure). If Felty syndrome is not treated, it can progress and lead to a number of complications, such as rheumatoid vasculitis, persistent joint deterioration requiring arthroplasty, and Felty syndrome requiring splenectomy. Since there is no known cure for RA, the goals of treatment are to reduce discomfort and stop/slow further damage. Moringa oleifera Lam., popularly known as munga, is one of the most significant plants that is widely cultivated in India. Moringa oleifera Lam is a plant that is widely used as a dietary supplement. It possesses valuable pharmacological qualities, such as anti-asthmatic, anti-diabetic, hepatoprotective, anti-inflammatory, anti-cancer, antimicrobial, anti-oxidant, cardiovascular, anti-ulcer, CNS activity, anti-allergic, wound healing, analgesic, and antipyretic action. In every area, this herb has excellent therapeutic qualities. It is a good source of vitamin A, vitamin C, and milk protein. The numerous active phytoconstituents present include alkaloids, proteins, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil, and lipids, to name just a few.
Aim and Objective: The current study's objective was to assess the anti-arthritic efficacy of M. oleifera leaves.
Method: In -silico molecular modelling studies for assessment of anti-arthritic potential of M. oleifera leaf was designed taking quercetin and niazirinin as lead molecule found in the ethanolic leaf extract (as per literature survey) against GLS-1 protein. A grid-based docking strategy was used to determine the binding using the Auto Dock software. 
Result: The finding of molecular modelling of lead molecule with GLS-1 protein showed that both the selected molecules have good affinity towards GLS-1 protein. The binding energy of quercetin and niazirinin against GLS-1 protein was found to be -4.8 & -5.94 Kcalmol-1 respectively.

Pages: 44-48  |  633 Views  266 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Jitender Malik, Deepak Jhariya, Priyanka Ahirwar, Shikha Sharma, Sadhana Upadhyay and Himesh Soni. Mechanistic insight anti-arthritis efficacy of bio-actives of Moringa oleifera: In-silico molecular docking. J Pharmacogn Phytochem 2024;13(1):44-48. DOI: 10.22271/phyto.2024.v13.i1a.14812

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