Mihir Gadani, Ratna Upadhyay and Sneha Badak

CollaBZen^TM from Zenherb labs, a proprietary blend of polyphenols extracted from Phyllanthus emblica, Camellia sinensis, and Coffea arabica, was assessed for its anti-ageing potential. Human dermal fibroblast and chondrocyte cells were exposed in vitro to hydrogen peroxide and UVA to induce ageing manifested as ROS production and collagen breakdown respectively.

CollaBZen^TM revealed no cytotoxicity up to 0.16 mg/ml in both NHDF and HCH cells. DCFDA assay revealed that CollaBZen^TM demonstrated a dose-dependent reduction in H₂O₂-induced ROS levels in both cell types. Exposure to UVA rays led to collagen depletion but CollaBZen^TM pre-treatment showed higher collagen levels, offering protection. At 0.04 mg/ml, it conferred a significant shield against UVA rays, with a 48.13%, 39.47%, and 30.5% increase in COL1A1, COL4A1, and COL2A1, respectively. Beyond promoting collagen as documented in the previous studies, CollaBZen^TM emerges as a potent food supplement safeguarding skin and joint cells from ageing consequences, reinforcing its role in age-related preventive care.

DOI: 10.22271/phyto.2024.v13.i2a.14864

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