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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 13, Issue 3 (2024)

A concentrated phenolic compounds extract from Khaya grandifoliola CDC exhibits anti-oxidant and anti-TNFα activities

Author(s):

Ridel Mbiandou Njami, Ferdinand Kouoh Elombo, Sylvain Nsangou Pechangou, Bradley Bolling, Frederic Nico Njayou and Paul Fewou Moundipa

Abstract:

A concentrated phenolic compounds extract (KPE) from the plant Khaya grandifoliola was assessed in vitro for antioxidant and anti-inflammatory properties and its effect on erythrocytes Plasma Membrane Redox System (PMRS). Phenolic compounds quantity per g of dry matter (DM) were total phenols (57. 93±0.42mg EGA) and flavonoids (2.84±0.04 mg EQ). Antiradicalar half scavenging concentrations were 6.25±0. 07 μg/mL and 11.65±0.92 μg/mL for DPPH° and HO° tests, respectively. Total Antioxidant Capacity was 76.82±0.35 mgEq AA/g DM and half inhibitory concentrations (IC50) of 8.50±0.14 µg/mL, 8.7±0.14 µg/mL and 71.05±1.20 µg/mL found for inhibition of lipids and proteins oxidation and TNFα production in Jurkat T cells, respectively. KPE activated erythrocytes PMRS with an EC50 of 5.90±0.00 µg/mL. Conclusively, KPE may be suggested as potential ingredient of functional foods against health conditions involving oxidative stress and inflammation.

Pages: 06-12  |  130 Views  68 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Ridel Mbiandou Njami, Ferdinand Kouoh Elombo, Sylvain Nsangou Pechangou, Bradley Bolling, Frederic Nico Njayou and Paul Fewou Moundipa. A concentrated phenolic compounds extract from Khaya grandifoliola CDC exhibits anti-oxidant and anti-TNFα activities. J Pharmacogn Phytochem 2024;13(3):06-12. DOI: 10.22271/phyto.2024.v13.i3a.14936

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