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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 13, Issue 3 (2024)

Antiproliferative potential of Ficus auriculata fruit extract on A549 cell lines: Insights from gene expression analysis

Author(s):

Roma Lal, Dr. Sunita Singh and Dr. Maneesha Pandey

Abstract:

Ficus auriculata fruit have gained attention for their potential health benefits, particularly their antioxidant and anticancer properties. The study was aimed to analyse anticancer activity of these fruits. Three different solvents (hexane, methanol, and water) were used for extraction. Phytochemical analysis, antioxidant activity and anticancer potential was evaluated on A549 and L132 cell lines. DNA damage patterns were analysed using the comet assay, and gene expression of epigenetic modulators was examined via qRT-PCR. The study found that the methanolic extract had a high phenolic content and strong antioxidant activity, effectively scavenging free radicals. Both the methanolic and water extracts demonstrated potent anticancer effects on A549 cells. DNA damage analysis indicated potential mechanisms of their anticancer action, with observed double-strand DNA damage in A549 cells. Gene expression analysis revealed intriguing decreased epigenetic modulators except HAT. Ficus auriculata fruit extracts, particularly the methanolic and water extracts, exhibit promising antioxidant and anticancer properties.

Pages: 279-290  |  133 Views  54 Downloads


Journal of Pharmacognosy and Phytochemistry Journal of Pharmacognosy and Phytochemistry
How to cite this article:
Roma Lal, Dr. Sunita Singh and Dr. Maneesha Pandey. Antiproliferative potential of Ficus auriculata fruit extract on A549 cell lines: Insights from gene expression analysis. J Pharmacogn Phytochem 2024;13(3):279-290. DOI: 10.22271/phyto.2024.v13.i3d.14968

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