Mbang A Owolabi, Esther M Soremi, Samson O Ajala and Celina O Ogah

Concomitant administration of herbs with orthodox drugs has attracted more attention as it can modify the pharmacokinetics of drugs thus causing adverse drug reaction or ineffective drugs. Therefore, the influence of a polyherbal formulation and its constituent, Markhamia tomentosa (MT) on the pharmacokinetics fate of a commonly prescribed antihypertensive drug, amlodipine was investigated. The polyherbal and its constituent, were extracted with 70% methanol, concentrated and freeze dried. Acute toxicity, flavonoid and phenol contents were evaluated. Human volunteers were given amlodipine (10 mg/kg, p.o) with or without MT (200 mg/kg, p.o) or polyherbal (eq. of 200 mg/kg MT); blood was drawn at different time, plasma assayed for the concentrations of amlodipine. Co-administration of amlodipine with MT showed significant (p≤0.05) increase in k_a, T_max, MRT and Vd with simultaneous decrease in k_el, C_max, and AUC_0-96. The administration of the polyherbal formulation showed little or no significance (p≥0.05); however, the k_a was slower, evident by decreased t_1/2 k_a and AUC_0-96. These findings suggest cautious use of MT or the polyherbal formulation with amlodipine to prevent pharmacokinetic alteration of amlodipine and posing threat to health.

DOI: 10.22271/phyto.2024.v13.i6a.15155

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