Manimaaran A, Sivaraj C, Dinesh MG, Divyapriya K and Nivetha B

Myristica fragrans is an important medicinal plant that belongs to the Myristicaceae family. It is used to treat muscular pain, nervous-related problems, asthma, bronchitis, lymphatic ailments, kidney problems, piles, and spleen disorders in Ayurveda. The present study aimed to evaluate the antioxidant and antibacterial activities of aril aqueous extract of M. fragrans and GC-MS analysis for active compound identification. Different antioxidant assays were carried out to evaluate the antioxidant capacity of the aril aqueous extract of M. fragrans. The maximum DPPH radical scavenging activity of aril aqueous extracts was 69.04±0.95% at 600 µg/mL concentration and the IC50 was 491.40 µg/mL concentration. The maximum superoxide radical scavenging activity of M. fragrans extract was 73.14±0.38% at 300 µg/mL concentration and the IC50 was 192.38 µg/mL concentration. The maximum ABTS●+ radical cation scavenging activity of aril aqueous extract was 70.59±0.77% at 30 µg/mL concentration and the IC50 was 4.28 µg/mL concentration. The maximum OH● radical scavenging activity was 50.23±1.47% at 300 µg/mL concentration and the IC50 was 298.62 µg/mL concentration. The maximum Fe3+ reduction and Mo6+ reduction were 55.06±1.02% and 94.25±0.19% at 300 µg/mL concentration and their RC50 were 270.44 µg/mL and 88.71 µg/mL concentration respectively. The antibacterial activity showed a maximum zone of inhibition of 20 mm against Staphylococcus aureus at 500 µg/mL concentration. GCMS analysis of aril aqueous extract of M. fragrans showed a markable active compound, Quinoxaline,2-isopropyl-3-phenyl-,4-oxide and its derivatives showed potential antibacterial activity.

DOI: 10.22271/phyto.2024.v13.i6e.15211

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