Deepali Sunil Deore, Prajakta Pramod Bacchav and Rohit Sachin Dighe

Purpose: This review aims to evaluate the efficacy of Akkalkara (Anacyclus pyrethrum) in improving voice quality and treating throat ailments. By exploring its traditional uses, phytochemical composition, pharmacological actions, and existing scientific studies, we seek to understand how Akkalkara contributes to vocal health and throat relief.

Methods: A comprehensive analysis was conducted using traditional Ayurvedic texts, peer-reviewed scientific literature, and pharmacological research. The review focuses on:

• Historical applications of Akkalkara for voice enhancement and throat remedies.
• Identification of active phytochemical constituents responsible for therapeutic effects.
• Examination of in vitro and in vivo studies illustrating mechanisms of action.
• Assessment of clinical observations and anecdotal evidence supporting its use.

Key Findings

• Traditional Efficacy: Historically, Akkalkara has been used to enhance voice clarity, reduce hoarseness, and soothe throat irritations. Singers and speakers have utilized it to strengthen vocal cords and improve articulation.
• Phytochemical Composition: The herb contains active compounds like pellitorine and anacycline, which exhibit anti-inflammatory, analgesic, and antimicrobial properties essential for throat health.

Mechanisms of Action

• Anti-Inflammatory Effects: Reduces inflammation in throat tissues, alleviating soreness and hoarseness.
• Analgesic Properties: Provides pain relief from throat discomfort.
• Antimicrobial Activity: Effective against certain bacteria causing throat infections, such as Streptococcus species.
• Neurostimulatory Actions: Stimulates nerves in the oral cavity and throat, potentially enhancing vocal cord function and control.

Scientific Evidence: Pharmacological studies support Akkalkara's efficacy in reducing inflammation and combating microbial infections affecting the throat. However, clinical trials in humans are limited, with most evidence stemming from traditional use and preliminary research.

DOI: 10.22271/phyto.2025.v14.i2f.15321

Pages: 463-476  |  131 Views  58 Downloads