Faisal Khan, Mohib Khan and Amina Parkar

Rauvolfia serpentina (Indian snake root) is a medicinal plant with a wide range of pharmacological activities, attributed primarily to its alkaloid content, particularly reserpine. Traditionally used in India and Southeast Asia, it has proven therapeutic effects for treating hypertension, cardiovascular diseases, psychiatric disorders, and diabetes. Extensive research highlights its diverse actions, including antihypertensive, anti-inflammatory, antioxidant, anti-cancer, and anti-diabetic properties. R. serpentina is also effective in managing bacterial, fungal, and venous toxicity, with additional benefits such as hepatoprotective and cardioprotective effects. Its alkaloids, especially ajmaline, have been shown to support glucose utilization and lower blood pressure. Despite its therapeutic potential, R. serpentina carries a risk of side effects, including gastrointestinal disturbances, depression, and sexual dysfunction, particularly with overdose. Toxicity concerns such as weight gain, increased appetite, and potential psychiatric symptoms are noted. Given its wide range of applications, R. serpentina holds promise as a natural remedy, but further pharmacological and toxicological investigations are necessary to optimize its use and ensure safety in clinical settings.

Pages: 277-284  |  2123 Views  1471 Downloads