Dikshanti Suresh Matre, Ramesh D Sonwane and Uday K Neralkar

Background: Ayurveda, the ancient Indian system of medicine, emphasizes the balance of Doshas as the foundation of health. Panchakarma, the fivefold purification therapy, is a unique Ayurvedic approach designed to eliminate accumulated toxins and restore homeostasis. Among these procedures, Virechana Karma (therapeutic purgation) is considered the most effective method for the elimination of aggravated Pitta Dosha and its associated morbidities.

Objective: The aim of this review is to present a detailed account of the principles, indications, classical descriptions, and contemporary clinical relevance of Virechana Karma.

Methods: Classical Ayurvedic literature was reviewed alongside modern clinical studies and scientific discussions on the role of Virechana. The therapeutic scope, mechanisms, and outcomes of this procedure have been highlighted.

Results: Virechana is described as a safe and effective purification therapy that provides systemic detoxification and improves metabolic efficiency. It has been traditionally indicated in disorders such as Kushta (skin diseases), Kamala (jaundice), Prameha (diabetes), Arsha (piles), Amavata (rheumatoid arthritis), and neurological conditions like migraine. Modern clinical observations show improvements in metabolic regulation, reduction in inflammatory markers, and better quality of life after undergoing Virechana. Compared to other Panchakarma procedures, it is associated with minimal stress, wider applicability, and sustained therapeutic effects.

Conclusion: Virechana Karma is a cornerstone of Panchakarma therapy with both preventive and curative potential. It offers holistic detoxification, enhances digestion and metabolism, and serves as an effective intervention for a variety of chronic, metabolic, autoimmune, and dermatological conditions. Its relevance in the management of modern lifestyle disorders highlights the need for further clinical validation and integration into contemporary healthcare systems.

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