N’guessan Ocho Esther, Kablan Ahmont Landry Claude, Ouattara Logopho Hyacinthe, Kouakou Sylvain Landry, Kablan Richmond Jean-François, Akoubet-Ouayogode Aminata and Sima Obiang Cédric

Diabetes is a growing public health issue in Côte d'Ivoire, linked to urbanization, sedentary lifestyles, and dietary changes. Many patients turn to traditional medicine. This study investigated MN, an antidiabetic herbal product from Korhogo composed of Anogeissus leiocarpus, Aloe vera, Chrysanthellum indicum, and Monodora tenuifolia. Phytochemical screening (in vitro, TLC) of its ethanolic extract revealed alkaloids and polyphenols. NMR spectroscopy (¹H, ¹³C, COSY, HMBC, NOESY) identified (+)-magnoflorine, a bioactive aporphine alkaloid. Acute toxicity testing (OECD 423) indicated MN is non-toxic (LD₅₀ > 2000 mg/kg bw). In glucose tolerance tests, oral MN (140 mg/kg bw) significantly lowered blood glucose levels, comparable to metformin (3 g/kg bw). These findings support MN’s antidiabetic potential and traditional use in Côte d’Ivoire.

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