Dipmala D Ghorpade, Aditya Santosh Autade, Bhagyashri A Vibhute, Vaishnavi J Patil, Pooja N Bhavar and Gajanan Sanap

Corn silk, the stigmas and styles of Zea mays L., has been utilized in traditional medicine across various cultures for its diuretic, anti-inflammatory, and litholytic properties. This review synthesizes current evidence on its phytochemical profile and therapeutic applications, particularly in treating urolithiasis (kidney stones), a prevalent condition affecting millions globally. Phytochemical analysis reveals a rich composition of flavonoids (e.g., luteolin, apigenin), phenolic acids, polysaccharides, and sterols, which underpin its bioactivities. Pharmacological studies demonstrate a ntioxidant, anti-inflammatory, hypoglycemic, and antihypertensive effects, with emerging data highlighting its role in mitigating calcium oxalate (CaOx) crystal formation, reducing oxidative stress, and enhancing urinary excretion of stone-forming substances In vitro and in vivo models show corn silk extracts inhibit crystal adhesion to renal cells, modulate urine pH, and boost citrate/magnesium levels, thereby preventing stone nucleation and growth Clinical insights, though limited, support its adjunctive use in stone expulsion Safety profiles indicate low toxicity, positioning corn silk as a promising natural adjunct for urolithiasis and related renal disorders. Future randomized trials are warranted to validate efficacy and standardize formulations. This narrative review draws from over 25 peer-reviewed sources to underscore corn silk's multifaceted potential in pharmacy practice.

Pages: 202-205  |  100 Views  33 Downloads