Sneha Tulavi, Babasaheb Ghumare, VV Karande, VR Patodkar, SB Lambate and VS Dhaygude

The present study was undertaken to evaluate the anti-inflammatory and analgesic activities of ethanolic extracts of Actinidia deliciosa and Vitis vinifera using experimental rodent models. Anti-inflammatory activity was evaluated using Complete Freund’s Adjuvant (CFA)-induced arthritis in Wistar rats, while analgesic activity was assessed using Eddy’s hot plate method in mice. Ethanolic extracts of A. deliciosa and V. vinifera were administered orally at a dose of 250 mg/kg. Indomethacin (2 mg/kg) served as the standard anti-inflammatory drug. CFA-induced arthritic rats showed significant joint swelling and reduction in body weight. Treatment with both plant extracts significantly reduced joint diameter and improved body weight compared to arthritic control animals (p<0.05). In the hot plate test, both extracts significantly increased reaction time, indicating analgesic activity, with peak effects observed between 60 and 120 minutes post-administration.

The findings suggest that ethanolic extracts of Actinidia deliciosa and Vitis vinifera possess significant anti-inflammatory and analgesic properties and may serve as potential natural therapeutic agents for inflammatory disorders.

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