Vol. 9, Issue 4 (2020)
Effect of the aqueous extract of Catharanthus roseus leaves against hypertention induced by fructose in rats
Author(s): Benoît Yoro, Calixte Bahi, Gnahoué Gouéh, Jean Noel Yapi and Serge Djoudori Koné
Abstract: Catharanthus roseus is a plant native to Madagascar. It is used for both ornamental and medicinal purposes. In traditional medicine, the leaves and roots of this plant are used in the treatment of many diseases. Studies on wistar rats showed that 60 % fructose consumption significantly induced (p<0, 0001) diabetes and high blood pressure (HTA) in these animals after 30 days. Treatment of these animals with the aqueous extract (EA) of Catharanthus roseus leaves showed a very significant decrease in blood glucose and cardiovascular parameters after seven days (p<0, 001). This decrease was observed at doses ranging from 200 to 1000 mg/kg. Compared with metformin, the aqueous extract has been shown to be effective. But compared to nifedipin NIFE 20 mg/kg dose gave satisfactory but not significant results compared to that of the EA 1000 mg/kg dose. The aqueous extract makes it possible to restore the homeostatic balance of the glycemic and cardiovascular parameters by reducing the values obtained after induction to values that are sensitive to those observed in the control.
How to cite this article:
Benoît Yoro, Calixte Bahi, Gnahoué Gouéh, Jean Noel Yapi, Serge Djoudori Koné. Effect of the aqueous extract of Catharanthus roseus leaves against hypertention induced by fructose in rats. J Pharmacogn Phytochem 2020;9(4):38-44.