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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 7, Special Issue 1 (2018)

Anticonvulsants and anti-nociceptive effect of ziziphus xylopyrus wild (Rhamnaceae) stem bark ethanolic extract

Author(s):

Usha Kumari Sah and Bhabagrahi Ratha

Abstract:
The available synthetic analgesic and anti-nociceptive drugs possess several health problem during their clinical use. To avoid these ill effect on health, it is necessary to search or develop a more effective drug with fewer side effects. Hence, the present investigation was carried out to test anticonvulsant effect and anti-nociceptive effect <em>Ziziphus Xylopyrus </em>(Retz.) Willd bark ethanolic extract. The anticonvulsant effect was done using using Maximum Electo Shock (MES) induced convulsion in rats. The extract (200 mg/kg p.o) significantly increased the threshold of MES-induces convulsion in rat compared with the control group. Which showed 83.34% protection in rat. The anti-nociceptive effect was done using tail flicl method. A maximum effect was 10.9 sec at 120 min post treatment with 200mg/kg p.o. <em>Ziziphus xylopyrus</em> (Retz.) Willd is effcetive. Where in the vehicle treat control group the reaction was 4.8 sec. Thus, <em>Ziziphus Xylopyrus </em>(Retz.) Willd bark is very useful medicinal plants besides its several economical use. The ethanolic extract is useful for epilepsy and pain as suggested dose.

Pages: 3228-3231  |  1273 Views  235 Downloads

How to cite this article:
Usha Kumari Sah and Bhabagrahi Ratha. Anticonvulsants and anti-nociceptive effect of ziziphus xylopyrus wild (Rhamnaceae) stem bark ethanolic extract. J Pharmacogn Phytochem 2018;7(1S):3228-3231.

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