Author(s):

Jayashree Pattar, Shridhar NB, Suhasini K and Satyanarayana ML

Abstract: The methanolic leaf extract of <em>Ficus virens </em>was evaluated for protective role and phytotoxic effect in Wistar albino rats. Preliminary phytochemical analysis was carried out by using HPTLC. For studying the protective role, rats divided into<em> </em>G1, G2, G3 as normal, CCl₄, standard (Vit-C @ 200 mg/kg) control and G4, G5, G6 as test groups treated with extract 50,100 and 150 mg/kg BW respectively for 7 days. Oxidative stress has been induced by CCl₄(1:1 liqiud paraffin @ 1ml/kg) after 6 h of the last treatment to all animals of G2 to G6. On day 8^th blood samples and liver tissue processed for different antioxidant enzyme activity including lipid peroxidation. For phytotoxic study, repeated dose 28-day oral toxicity was carried at limit dose of 1000 mg/kg. Phytochemical analysis study showed that extract is positive for carotenoids, flavonoids, phenols and negative for alkaloids. Pre-treatment with extract prevented lipid peroxidation and showed significant increase antioxidant enzyme activity. Phytotoxic study showed that no change in biochemical and haematological, gross and histopathological changes noticed, hence no observed adverse effects of <em>F. virens</em> in rats was determined at dose 1000 mg/kg.

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