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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 7, Special Issue 6 (2018)

Formulation and evaluation of 5-fluorouracil buccal mucoadhesive buccal tablet

Author(s):

Nitin Gawai and Zahid Zaheer

Abstract:
<strong>Objective: </strong>The present formulation was developed with the intention to formulate versatile 5-fluorouracil (5-FU) mucoadhesive tablet that fulfill the therapeutic need that is lacking in current cancer treatment and aimed at minimizing toxic effect, enhancing efficacy and increasing patient compliance. <strong>Method: </strong>Mucoadhesive tablets of 5-fluorouracil were prepared by direct compression technique using different grades of polymer with varying concentration. The tablets were compressed using 10 mm flat faced punch on a single stroke-punching machine. The formulations were tested for drug content, hardness, friability, weight variation, thickness, swelling studies, in vitro drug release, ex vivo permeation studies, mucoadhesive strength. <strong>Result and Discussion: </strong>The formulated mucoadhesive buccal tablet was evaluated for various parameter and formulation F7 was found as the optimum batch. <strong>Conclusion: </strong>From the above study it was concluded that Formulation F7 was found optimized formulation showing optimum results for all the evaluated parameters. The drug content was 98.75%, swelling index 130 at 6 hours, Mucoadhesive Strength 22.1 and force (N) 0.216801, Residence time was more than 8hours and drug release was found to be 96.78%.

Pages: 19-23  |  1136 Views  163 Downloads

How to cite this article:
Nitin Gawai and Zahid Zaheer. Formulation and evaluation of 5-fluorouracil buccal mucoadhesive buccal tablet. J Pharmacogn Phytochem 2018;7(6S):19-23. DOI: 10.22271/phyto.2018.v7.isp6.1.05