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Journal of Pharmacognosy and Phytochemistry

Journal of Pharmacognosy and Phytochemistry

Vol. 7, Special Issue 6 (2018)

Guggulsterone –Farnesoid X receptor interaction

Author(s):

Prutha Parmar, Swarali Bhoir, Pravin P Naik, Sandeep Waghulde, Nilesh Gorde and MK Kale

Abstract:
Guggulsterone is a plant sterol derived from gum resin of Commiphora wightii. The gum resin from guggul plants has been used for thousand years in Ayurveda to treat various disorders, including internal tumors, obesity, liver disorders, malignant sores and ulcers, urinary complaints, intestinal worms, leucoderma, sinuses, edema, and sudden paralytic seizures. Guggulsterone has been identified a bioactive components of this gum resin. This plant steroid has been reported to work as an antagonist of certain nuclear receptors, especially farnesoid X receptor, which regulates bile acids and cholesterol metabolism. Authors are interested to study Guggulsterone – Farnesoid X receptor interactions. Interactions were studied on Molecular Operating Environment software and the interactions of guggulsterone confirms its activity at Farnesoid X receptor.

Pages: 107-114  |  1987 Views  567 Downloads

How to cite this article:
Prutha Parmar, Swarali Bhoir, Pravin P Naik, Sandeep Waghulde, Nilesh Gorde and MK Kale. Guggulsterone –Farnesoid X receptor interaction. J Pharmacogn Phytochem 2018;7(6S):107-114. DOI: 10.22271/phyto.2018.v7.isp6.2.22

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