Author(s):

Mukesh Kumar, Samar Jyoti Chutia, Avinash Talukdar, Jyotismita Thakuria and Vishwambhar Vishnu Bhandare

Abstract: The Insilco experiment was conducted to find out small drug or ligand which can able to bind Gonadotropin releasing hormone receptor of <em>Monopterus cuchia</em>. GnRH receptor are G protein coupled receptor for this purpose ligand selected on basis of GPCR ligand, Ion channel modulator, Kinase inhibitor, Nuclear receptor ligand, Protease inhibitor, Enzyme inhibitor activity. Compound selected based on ADMET property. In this present Study modified protocol followed which help us to find compound which is less toxic or nontoxic to fish as our target organism is fish.

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