Journal of Pharmacognosy and Phytochemistry
Vol. 8, Special Issue 5 (2019)
Haemato-biochemical changes in grower broilers on sub-acute allopurinol toxicity
Sanjiv Kumar, MK Gupta, Sanjit Kumar and Brajesh Kumar
The experiment was conducted to explore subacute toxic effect of feeding allopurinol in grower broiler birds as an anti-gout medication. Gout is a systemic disease that results from the deposition of monosodium urate crystals (MSU) in tissues. Uric acid is synthesized in liver from purines where the last two reactions is mediated by xanthine oxidase. Allopurinol is an xanthine oxidase inhibitor which is frequently used as an anti-gout drug in human medicine and well used in treating poultry gout during the last few years. In our experiment grower broilers were fed allopurinol @ 250mg/kg b. wt. orally for seven days and thereafter blood was collected to determine haemato-biochemical changes. Biochemical studies revealed that the value of urea increased while creatinine and globulin values were decreased in allopurinol treated group than the control group of birds but the variation was non-significant statistically. Haematological studies showed that there was increase in the value of total leucocyte count and at the same time decrease in total erythrocyte count in birds of treatment group in comparison to control group, though the variation was non-significant. A significant increase in the number of heterophil count was observed but lymphocyte count was significantly decreased. There was no statistical difference in monocyte and eosinophil count. It appears that allopurinol has some irritating nature and mild effect on kidneys though not enough to cause any overt deleterious effect and may be recommended for use in broiler at therapeutic dose.
Pages: 390-392 | 1089 Views 199 Downloads
Sanjiv Kumar, MK Gupta, Sanjit Kumar and Brajesh Kumar. Haemato-biochemical changes in grower broilers on sub-acute allopurinol toxicity. J Pharmacogn Phytochem 2019;8(5S):390-392.