Author(s):

Dora Babu Neerugatti, Mallikarjuna Rao Talluri and Ganga Rao Battu

Abstract: The present study, cytotoxicity activity of the methanolic extracts of some folklore medicinal (Buchanania axillaris Desr, Tamilnadia ulignosa Retz, Phaseolus semierectus L and Stylosanthes fruticosa Retz) was evaluated on human cancer cell lines such as colon cancer (HT-29) and breast cancer (MCF-7 and MDA-MB) using MTT assay method. The selected plant extracts showed the dose dependent cytotoxicity activity on the tested cell lines. The cytotoxicity variations on different cell lines were also observed for selected plants extracts. The cytotoxicity of the extracts were increased as the concentration of them was increased. Among all tested plants extracts Phaseolus semierectus showed the better cytotoxicity activity on tested cell lines. The results support the folkloric usage of the studied plants and confirmed that the studied plant possesses the constituents with cytotoxic properties that can be useful for developing new anticancer agents.

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