Author(s):

Ranjith D and Ravikumar C

Abstract: To bolster in drug discovery, authentic data on pharmacokinetics properties of the molecule must be attainable at the earliest which eventually contributes to the success or failure of the compound. The present study will be the first of its kind reporting the ADME (Absorption, Distribution, Metabolism and Excretion) properties of Ipomoea mauritiana Jacq using freely available web tool Swiss ADME. A sum total of 15 potential compounds reported in earlier work from Ipomoea mauritiana were screened for ADME properties and the results were analyzed hereafter. Among the compounds screened only 5 molecules showed good brain penetration viz. tetradecanal, tetradecanoic acid, dodecanoic acid, hexanoic acid, scopoletin and three with good GIT absorption viz. Octadecan-1-ol, octadecanoic acid and Chloroacetic acid. Most of the compounds are non-substrate for both P-gp (P-glycoprotein) and CYP (Cytochrome P-450 isoenzymes). All the compounds passed Lipinski’s rule of five to for drug likeness test. SwissADME emerged to be simple, robust and accurate method to understand the ADME properties of the compounds present in Ipomoea mauritiana.

Pages: 2063-2073  |  10983 Views  8421 Downloads

Download (964KB)