Materials and Method: Twenty- four adult male wistar rats with average age of 120-215 grams were purchased and used for this experiment. The rats were divided into six (6) groups of four (4) rats each. After 14days of acclimatization, the rats were grouped into control group (group A) and experimental groups (group B, C, D, E and F). The control group were given normal saline and feed. Group B rats were given 0.5ml of acetaminophen with 200mg/kg of aqueous extract. Group C received 0.5 ml of acetaminophen with 400mg/kg of aqueous leaf extract. Group D received 0.5ml of acetaminophen with 600mg/kg of aqueous leaf extract while Group E received 0.5ml of acetaminophen only. Group F were given standard drug, vitamin E orally for 10 days. The animal sacrificed on the 20^THday, and the organ was harvested for assaying brain function and histopathological test. Brain tissues were excised and fixed in formal saline then processed using the Hematoxylin and Eosin method.

Result: Administrations of aqueous leaf extract of S. macrocarpon shows moderate healing with mild condensed neurons (CN), mild microcytic space (MS) and some plasma cell (PC) secondary to acetaminophen (H/E) X (400) induced cortex degeneration with microcystic space (MS), shrinking of the neurons (SN),eosinophilic substance within the vacuolated space (ES) and moderate coagulative necrosis.

Conclusion: This present study proved that the aqueous extract of Solanum macrocarpon leaf exhibited a dose dependent significant antioxidant property on the brain against acetaminophen induced inflammation on the experiment rats. It is however recommended that further investigations should be carried on the efficacy and safety of use this extract on the brain and other tissues before recommending its use for certain medicinal.