Objectives: This study carried out the preliminary phytochemical screening, evaluated antioxidant activities, chromatographic and GC/MS of different solvents extracts of Bridelia ferruginea leaf.

Materials and Methods: Antioxidant activities, phytochemical screening, chromatographic analysis and GC/MS analysis were performed using standard methods.

Results: The phytochemical screening revealed the presence of various secondary metabolites such as alkaloids, flavonoids amongst others. The extract demonstrated some antioxidant activities. The GC/MS of various fractions revealed Palmitic acid, vinyl ether, E-heptadecenal,4.4,6a,6b,8a,11,12,14b-octamethy l,12a14,14a,14b-octadecahydro-2h-picen-3–one,:2,2,6-trimethyl-1-(2-methylcyclobut-2-enyl)-hepta-4,6 dien-3-one;Hexadecanoicacid ethyl ether; Phytol; Neophytadiene and 2-Pentadecanone,6,10,14 trim ethyl as the most abundant constituents.

Conclusion: The study revealed that the multiple physiological and pharmacological and antioxidant activities of the plant extract could be attributed to the presence of secondary metabolites justifying local use of the plant and the claims by the traditional healers that the plant drug could be used to manage some disease states that might not be easily managed by orthodox medicines.