Author(s):

Dr. Prateek Mishra, Dr. Vidhi Gautam, Dr. RK Sharma, Dr. Anushri Tiwari and Dr. Alka Sawarkar

Abstract: Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. It includes various approaches, formulations, technologies and systems for transporting a pharmaceutical compound in body as needed to safely achieve its desired therapeutic effect Microneedles are three-dimensional (3D) microstructures with micro-scale length (usually <1000 μm) that can pierce the stratum corneum and generate transient micro-channels through which external molecules can passively diffuse into the skin. Microneedles could be designed in a manner that the penetration depth is superficial enough to not touch nerve receptors in the lower reticular dermis, this result in a painless drug administration. It is promising that this microneedle-based transdermal delivery approach will offer a self-management, patient-friendly, and efficient administration route for drug delivery. This system has increased its application to many fields like oligonucleotides delivery, vaccine delivery, insulin delivery, and even in cosmetics.

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